Marijuana compound may offer treatment for Alzheimer’s disease

Findings from the experiments, using a cellular model of Alzheimer’s disease, were reported online in the Journal of Alzheimer’s Disease.

Researchers from the USF Health Byrd Alzheimer’s Institute showed that extremely low doses of THC reduce the production of amyloid beta, found in a soluble form in most aging brains, and prevent abnormal accumulation of this protein — a process considered one of the pathological hallmarks evident early in the memory-robbing disease. These low concentrations of THC also selectively enhanced mitochondrial function, which is needed to help supply energy, transmit signals, and maintain a healthy brain.

“THC is known to be a potent antioxidant with neuroprotective properties, but this is the first report that the compound directly affects Alzheimer’s pathology by decreasing amyloid beta levels, inhibiting its aggregation, and enhancing mitochondrial function,” said study lead author Chuanhai Cao, PhD and a neuroscientist at the Byrd Alzheimer’s Institute and the USF College of Pharmacy.

“Decreased levels of amyloid beta means less aggregation, which may protect against the progression of Alzheimer’s disease. Since THC is a natural and relatively safe amyloid inhibitor, THC or its analogs may help us develop an effective treatment in the future.”

The researchers point out that at the low doses studied, the therapeutic benefits of THC appear to prevail over the associated risks of THC toxicity and memory impairment.

Neel Nabar, a study co-author and MD/PhD candidate, recognized the rapidly changing political climate surrounding the debate over medical marijuana.

“While we are still far from a consensus, this study indicates that THC and THC-related compounds may be of therapeutic value in Alzheimer’s disease,” Nabar said. “Are we advocating that people use illicit drugs to prevent the disease? No. It’s important to keep in mind that just because a drug may be effective doesn’t mean it can be safely used by anyone. However, these findings may lead to the development of related compounds that are safe, legal, and useful in the treatment of Alzheimer’s disease.”

The body’s own system of cannabinoid receptors interacts with naturally-occurring cannabinoid molecules, and these molecules function similarly to the THC isolated from the cannabis (marijuana) plant.

Dr. Cao’s laboratory at the Byrd Alzheimer’s Institute is currently investigating the effects of a drug cocktail that includes THC, caffeine as well as other natural compounds in a cellular model of Alzheimer’s disease, and will advance to a genetically-engineered mouse model of Alzheimer’s shortly.

“The dose and target population are critically important for any drug, so careful monitoring and control of drug levels in the blood and system are very important for therapeutic use, especially for a compound such as THC,” Dr. Cao said.

Source: sciencedaily
Filed Under: Science Daily

Marijuana compound may offer treatment for Alzheimer’s disease

Findings from the experiments, using a cellular model of Alzheimer’s disease, were reported online in the Journal of Alzheimer’s Disease.

Researchers from the USF Health Byrd Alzheimer’s Institute showed that extremely low doses of THC reduce the production of amyloid beta, found in a soluble form in most aging brains, and prevent abnormal accumulation of this protein — a process considered one of the pathological hallmarks evident early in the memory-robbing disease. These low concentrations of THC also selectively enhanced mitochondrial function, which is needed to help supply energy, transmit signals, and maintain a healthy brain.

“THC is known to be a potent antioxidant with neuroprotective properties, but this is the first report that the compound directly affects Alzheimer’s pathology by decreasing amyloid beta levels, inhibiting its aggregation, and enhancing mitochondrial function,” said study lead author Chuanhai Cao, PhD and a neuroscientist at the Byrd Alzheimer’s Institute and the USF College of Pharmacy.

“Decreased levels of amyloid beta means less aggregation, which may protect against the progression of Alzheimer’s disease. Since THC is a natural and relatively safe amyloid inhibitor, THC or its analogs may help us develop an effective treatment in the future.”

The researchers point out that at the low doses studied, the therapeutic benefits of THC appear to prevail over the associated risks of THC toxicity and memory impairment.

Neel Nabar, a study co-author and MD/PhD candidate, recognized the rapidly changing political climate surrounding the debate over medical marijuana.

“While we are still far from a consensus, this study indicates that THC and THC-related compounds may be of therapeutic value in Alzheimer’s disease,” Nabar said. “Are we advocating that people use illicit drugs to prevent the disease? No. It’s important to keep in mind that just because a drug may be effective doesn’t mean it can be safely used by anyone. However, these findings may lead to the development of related compounds that are safe, legal, and useful in the treatment of Alzheimer’s disease.”

The body’s own system of cannabinoid receptors interacts with naturally-occurring cannabinoid molecules, and these molecules function similarly to the THC isolated from the cannabis (marijuana) plant.

Dr. Cao’s laboratory at the Byrd Alzheimer’s Institute is currently investigating the effects of a drug cocktail that includes THC, caffeine as well as other natural compounds in a cellular model of Alzheimer’s disease, and will advance to a genetically-engineered mouse model of Alzheimer’s shortly.

“The dose and target population are critically important for any drug, so careful monitoring and control of drug levels in the blood and system are very important for therapeutic use, especially for a compound such as THC,” Dr. Cao said.

Source: sciencedaily
Filed Under: Science Daily

All-in-one organic soils

The “proving me wrong” part was related to my past experiences with bagged products (soils and composts) compared with my experiences now that I am mixing my soil from scratch. I’m honestly not trying to stir anything up, here; just trying to help others learn from my experiences (if that makes sense).

I do a whole lot of reading, and I see the same progression over and over and over and over again. People start with big-name bagged soils like Fox Farms or Roots, and pour bottled nutrients over them. Then maybe they try a “boutique” soil aimed at the MJ industry, like Empire Builder or a handful of others. Then they start adding some various amendments to the soil, maybe even start brewing compost teas. Then they maybe try a popular “supersoil” recipe, again using the store-bought bags of “base soil” and bagged worm castings. Then they mix up a batch of soil from scratch, maybe even start up a worm bin or a compost pile. Then they start re-amending and reusing their soil, and start phasing out products from the hydro shop in favor or simple, pure ingredients like kelp, alfalfa, and neem meal. One thing you will notice no matter how much you read is that you VERY rarely will see someone go backward in the “progression” I just described. Why? Because the results just keep getting better!

I was one of those people, too. I followed just about every step I listed above, and I will NEVER go back. If I can save someone’s time, money, and effort by convincing them to skip one or two of the steps above, I believe they will thank me later.

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Cali connection genetics?

Discussion in ‘General Marijuana Growing’ started by trichome 1, Aug 22, 2014 at 7:29 AM.

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CFL Lighting Question Please HELP

Discussion in ‘General Marijuana Growing’ started by Monkman1985, Aug 27, 2014 at 10:11 AM.

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A small project cont……

Discussion in ‘Grow Room Design Setup’ started by Hank, Aug 27, 2014 at 3:32 AM.

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Black cop kills unarmed 20 yo white male

Why not mention the criminal history of this thug?

Taylor was facing a $25,000 arrest warrant for allegedly violating probation he received for robbery and obstructing justice;

he was arrested July 31 in North Salt Lake for being drunk and interfering with the arresting officer, according to an affidavit filed with the court.

Taylor also had failed to maintain full employment, complete a mental health evaluation or complete a substance abuse evaluation, all conditions of his probation, according to the affidavit.

Taylor expressed an intense feeling of doom, and determination not to go back to jail as a result of the warrant, issued Aug. 7.

“I feel my time is coming soon, my nightmears [sic] are telling me,” he wrote that day on Facebook. “ALL my family has turned and snitched on me. I’ll die before I go do a lot of time in a cell.

Third District Court records show that Taylor pleaded guilty to a reduced count of second-degree felony robbery in connection to thefts at a Beto’s restaurant and another 7-Eleven in South Salt Lake in May of 2012. Taylor’s co-defendant grabbed the tip jar at Beto’s, according to court documents. About an hour later, Taylor’s co-defendant stole a case of beer at a 7-Eleven at 2700 S. Adams St. (450 East). When the clerk followed him to a car, Taylor placed a hand into his waistband and told the man, “Don’t be a hero … or I’ll … shoot you,” according to court documents.

In an unrelated obstructing justice case in August 2012, Taylor threatened a co-defendant in the robbery case, as well as his wife and daughter, and called the co-defendant “a … snitch,” according to court documents.

If we can’t trust those witnesses in Ferguson, we can trust this thugs brother, he’s a fucking thug too. The dead thugs brother Jerrail Taylor, was released on parole April 23 after serving 26 months of a 0-to-15-year prison term, according to Department of Corrections spokeswoman Brooke Adams.

You guys should feel free to tell the truth about this thug too, he is not actually white. Did Limbaugh forget to cover this?

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Parasite!! help please.

Discussion in ‘Newbie Central’ started by sk8ntoke, Aug 27, 2014 at 2:19 PM.

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shooting instructor gets second amendmented to death by 9 year old girl with full auto uzi

Discussion in ‘Politics’ started by UncleBuck, Aug 27, 2014 at 4:35 PM.

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1st Journal — Aeroflo 60 (15) Cataract Indica Rookie

Week 2

Have had pretty good growth up top and really good growth at roots at start of week one in aeroflo you could see the tops were pretty small cuttings with a few fans each, bottom had thick roots barley pushing through the rockwool now a week later there is some pretty awesome growth (pics). I will, run a four week vegetation and almost exactly eight week flower (56 days, give or take). They’re under 600w mh and the hood is 3′ off the canopy now (see previous post) for 16/8 cycle. I will switch to 1000w over the next few days keeping same distance for a week and continue to move down to 14″ above canopy.

Week 2
ppm 840
ph 5.7
67°

One thing about aeroflo nobody’s going to tell you is… drop the water level until the holes in overflow tubes are just barely visible about an 1/2″ above the bottom of the tube, throughout the whole grow, yes set them and forget them. Expecially if your running rockwool, this keeps, the net cup out of the water and throws an aerated mist in the tubes and prevents water logging your rockwool (mold and cellular damage within the cube of rockwool also forces the roots to grow to the water). This was trial and error for me and if you dont believe me here, try it in one of your tubes and you’ll see for yourself, rapid root growth, almost amazing from day to day growth. Also if your not chilling water to 67°-68° on aeroflo your really doing yourself an injustice, you’ll never have anything but white healthy roots this way

Note: as long as you cleaned your machine diligently, including taking the caps off the end of your whips and blowing them out, I use h2o2 29% 10ml per gallon using 20 gallons and running the machine for 3 days empty rinse refill run again for 24 hours empty done.

I also use grow spray every other day on the tops to increase growth @ 15ml per liter per exnutrients directions. Really makes for, healthy bright green tops and extremely fast growth top and bottom.

exnutrients is cheaper than most but only uses the highest quality ingredients, will never clog your whips, and is made for aeroponics. Most of all…. produces tremendous growth as you’ll see through this grow. (No, I do not work for them just a fan of there products lol) Anyways be back on week 3.

please feel free to input your opinions, ideas, and/or suggestions. Respect

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